Use of scenario evaluation in preparation for deployment of a collaborative system for knowledge transfer - the case of KiMERA

This paper presented an approach for the evaluation of a collaborative system, after the completion of system development and software testing but before its deployment. Scenario and collaborative episodes were designed and data collected from users role-playing. This was found to be a useful step in refining the user training, in setting the right level of user expectation when the system started to roll-out to real users and in providing feedback to the development team

Geometric Actions for D-Branes and M-Branes

New forms of Born-Infeld, D-brane and M theory five-brane actions are found which are quadratic in the abelian field strength. The gauge fields couple both to a background or induced metric and a new auxiliary metric, whose elimination reproduces the non-polynomial Born-Infeld action. This is similar to the introduction of an auxiliary metric to simplify the Nambu-Goto string action. This simplifies the quantisation and dualisation of the gauge fields.Comment: LaTeX, 9 pages, no figures. Minor corrections; version to appear in Physics Letters

The molecular epidemiology of human immunodeficiency virus type 1 in six cities in Britain and Ireland

The authors sequenced the p17 coding regions of the gag gene from 211 patients infected either through injecting drug use (IDU) or by sexual intercourse between men from six cities in Scotland, N. England, N. Ireland, and the Republic of Ireland. All sequences were of subtype 5. Phylogenetic analysis revealed substantial heterogeneity in the sequences from homosexual men. In contrast, sequence from over 80% of IDUs formed a relatively tight cluster, distinct both from those of published isolates and of the gay men. There was no large-scale clustering of sequences by city in either risk group, although a number of close associations between pairs of individuals were observed. From the known date of the HIV-1 epidemic among IDUs in Edinburgh, the rate of sequence divergence at synonymous sites is estimated to be about 0.8%. On this basis it has been estimated that the date of divergence of the sequences among homosexual men to be about 1975, which may correspond to the origin of the B subtype epidemic

De Sitter Holography and the Cosmic Microwave Background

We interpret cosmological evolution holographically as a renormalisation group flow in a dual Euclidean field theory, as suggested by the conjectured dS/CFT correspondence. Inflation is described by perturbing around the infra-red fixed point of the dual field theory. The spectrum of the cosmic microwave background radiation is determined in terms of scaling violations in the field theory. The dark energy allows similar, albeit less predictive, considerations. We discuss the cosmological fine-tuning problems from the holographic perspective.Comment: 17 pages, 2 figures, uses JHEP style files; corrected and added reference

Reliability of fluctuation-induced transport in a Maxwell-demon-type engine

We study the transport properties of an overdamped Brownian particle which is simultaneously in contact with two thermal baths. The first bath is modeled by an additive thermal noise at temperature $T_A$. The second bath is associated with a multiplicative thermal noise at temperature $T_B$. The analytical expressions for the particle velocity and diffusion constant are derived for this system, and the reliability or coherence of transport is analyzed by means of their ratio in terms of a dimensionless P\'{e}clet number. We find that the transport is not very coherent, though one can get significantly higher currents.Comment: 14 pages, 5 figure

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis

Our objective was to identify whether rare genetic variation in amyotrophic lateral sclerosis (ALS) candidate survival genes modifies ALS survival. Candidate genes were selected based on evidence for modifying ALS survival. Each tail of the extreme 1.5% of survival was selected from the UK MND DNA Bank and all samples available underwent whole genome sequencing. A replication set from the Netherlands was used for validation. Sequences of candidate survival genes were extracted and variants passing quality control with a minor allele frequency ≤0.05 were selected for association testing. Analysis was by burden testing using SKAT. Candidate survival genes UNC13A, KIFAP3, and EPHA4 were tested for association in a UK sample comprising 25 short survivors and 25 long survivors. Results showed that only SNVs in UNC13A were associated with survival (p = 6.57 × 10−3). SNV rs10419420:G > A was found exclusively in long survivors (3/25) and rs4808092:G > A exclusively in short survivors (4/25). These findings were not replicated in a Dutch sample. In conclusion, population specific rare variants of UNC13A may modulate survival in ALS

Superfield T-duality rules

A geometric treatment of T-duality as an operation which acts on differential forms in superspace allows us to derive the complete set of T-duality transformation rules which relate the superfield potentials of D=10 type IIA supergravity with those of type IIB supergravity including Ramond-Ramond superfield potentials and fermionic supervielbeins. We show that these rules are consistent with the superspace supergravity constraints.Comment: 24 pages, latex, no figures. V2 misprints corrected. V3. One reference ([30]) and a comment on it ('Notice added') on p. 19 adde